English
missense
Missense comes from Middle English sense ‘meaning, signification’, from Old French sens ‘reason’, and ultimately from Proto-Indo-European *sent- ‘to perceive’.
- Proto-Indo-Europeanc. 4500–2500 BCE*sent-‘to perceive’reconstructed
- Proto-Italicc. 1500–700 BCE*sentiō‘to feel, to sense, to perceive’reconstructed
- Latinc. 75 BCE–200 CEsentiō‘to feel, to sense, to perceive’
- Latin, derivedc. 75 BCE–200 CEsēnsus‘perception, feeling, sensation’
- Proto-Germanicc. 500 BCE–200 CE*sinnaz‘sense, perception’reconstructed
- Frankishc. 250–700*sinnreconstructed
- Vulgar Latinc. 100–700 CE*sennus‘sense, reason’reconstructed
- Old Frenchc. 842–1400sens‘reason’
- Middle Englishc. 1150–1500sense‘meaning, signification’
- English1500–presentsame form
- Englishearliest quotation 2012missense
attested reconstructed ? uncertain or disputed
Lineage
- Proto-Indo-Europeanc. 4500–2500 BCE*sent-‘to perceive’reconstructed
- Proto-Italicc. 1500–700 BCE*sentiō‘to feel, to sense, to perceive’reconstructed
- Latinc. 75 BCE–200 CEsentiō‘to feel, to sense, to perceive’
- Latin, derivedc. 75 BCE–200 CEsēnsus‘perception, feeling, sensation’
- Proto-Germanicc. 500 BCE–200 CE*sinnaz‘sense, perception’reconstructed
- Frankishc. 250–700*sinnreconstructed
- Vulgar Latinc. 100–700 CE*sennus‘sense, reason’reconstructed
- Old Frenchc. 842–1400sens‘reason’
- Middle Englishc. 1150–1500sense‘meaning, signification’
- English1500–presentsame form
- Englishearliest quotation 2012missense
Earliest quotation: 2012, Stefan Bröer, Carsten A. Wagner: “One possibility is that if G6PT is a G6P…”
Proto-Indo-European *mey- ‘to change’
Proto-Indo-European *mitˢtós ‘mutual, reciprocal’
Proto-Germanic *missa- ‘wrongly, badly, mis-’
Proto-West Germanic *missa- ‘mis-, wrongly’
English mis-
Proto-Indo-European *sent- ‘to feel’
…
Latin sentiō ‘feel, perceive’
Latin sēnsus ‘sensation, feeling, meaning’
Old French sens ‘sense, perception, direction’
Middle English sense ‘meaning’
English sense
Linked words
through Proto-Indo-European *sent- ‘to perceive’
through Proto-Italic *sentiō ‘to feel, to sense, to perceive’
through Latin sentiō ‘to feel, to sense, to perceive’
sentence, sensitive, consent, sentiment, scent, consensus, sensible, sensor, resent, sensibility, sentient, assent, sentience, 30 more
through Latin sēnsus ‘perception, feeling, sensation’
sensation, sensual, sensuous, sensu, 17 more
through English sense
Today it means
noun A damaged DNA sequence that is meaningful but has an incorrect meaning, with the result that its products do not do what they are supposed to do.
Language periods are conventional ranges, not dates for this word.
Etymograph / Proto-Indo-European *sent- / missense